How can I participate?
Gut health!
Our researchers want to know more. Help our scientists and clinicians understand more about functional gut disorders by assisting with research.
You can help (whether you have gut disorders or not) by completing two short surveys (they will take between 10-20 minutes to complete).
The CRE in Digestive Health aims to better understand a range of digestive diseases that affect the whole spectrum of the gastrointestinal tract including:
- Reflux disease
- Eosinophilic Esophagitis
- Celiac Disease
- Non celiac wheat/gluten sensitivity
- Diverticular disease
- Inflammatory Bowel disease
- Ulcerative colitis
- Crohn’s disease
- Spirochaetosis
- Helicobacter pylori
- Primary Sclerosing Cholangitis
- Achalasia
- Unexplained (Functional) gastrointestinal diseases
- Irritable Bowel Syndrome
- Functional Dyspepsia
More than one third of Australians have chronic or relapsing unexplained gastrointestinal (GI) symptoms, including abdominal pain, abdominal fullness, unable to finish a normal meal, bloating, constipation or diarrhoea. For over 50% of patients with chronic gastrointestinal symptoms no structural or biochemical abnormality is found on routine testing, and they are referred to as Functional GI Disorders (FGIDs), most notably the irritable bowel syndrome (IBS) and functional dyspepsia. While not life-threatening these disorders are usually chronic, lasting for many years.
Digestive diseases are common in Australia and on the rise. The current lack of specific diagnostic tests or effective targeted treatments for people suffering with specific digestive diseases, especially unexplained functional gastrointestinal diseases places a significant burden of the individual, their families and the health care system.
Many patients with digestive diseases have a poorer quality of life compared to people without these disorders and also when compared to patients with other diseases such as coronary heart disease and diabetes mellitus. Digestive diseases can impact a person’s physical, mental and social functioning and ability to work ad study. Studies have shown that people with digestive diseases such as irritable bowel syndrome also have increased rates of psychological distress including anxiety and depression.
Digestive diseases also place a significant burden on the health care system. This is especially true for people with unexplained (functional) gastrointestinal diseases (FGIDs), as many people with these diseases frequently seek health care and undergo numerous diagnostic tests including blood tests, ultrasounds and endoscopy procedures to try and diagnose their symptoms. In America, irritable bowel syndrome alone is known to cost the economy $20 billion dollars each year and while Australian data on the costs are lacking it is expected to be comparably high.
The Centre of Excellence in Digestive Health is dedicated to improving the lives of people suffering from digestive diseases. We are working hard in the laboratories to better understand these disorders, to identify new ways to diagnose patients and to test novel targeted treatments for these disorders We are also developing a toolkit for patients, clinicians and researchers. The tool kit will provide educational content, research tools, and practical resources.
Investigators
Professor Nicholas J. Talley, AC, MD (NSW), PhD (Syd.), FRACP, FAFPHM, is a distinguished neurogastroenterologist and clinician, with a special interest in functional and eosinophilic gastrointestinal disorders.
Distinguished Laureate Professor Nicholas Talley, AC
Professor of Medicine and Neurogastroenterologist, University of Newcastle, Staff Specialist John Hunter Hospital, NHMRC Leadership Fellow
Professor Gerald Holtmann is an academic gastroenterologist with an outstanding track record in the field of Neurogastroenterology and Health Service Innovation.
Professor Gerald Holtmann
Director of Gastroenterology and Hepatology, Princess Alexandra Hospital and Associate Dean Clinical, Health Faculties, University of Queensland, QLD
Professor Walker is Professor of Anatomical Pathology at the University of Newcastle, HMRI and holds an honorary staff specialist post at John Hunter Hospital.
Professor Marjorie Walker
Professor of Anatomical Pathology, School of Medicine and Public Health, University of Newcastle, Staff Specialist John Hunter Hospital, NSW
Mark Morrison’s scientific expertise resides in the fields of microbial physiology, genetics and genomics, with a career-long focus on the gastrointestinal microbiota of humans and other herbivores.
Professor Mark Morrison
Chair of Microbial Biology and Metagenomics - The University of Queensland Diamantina Institut
Latest news
Advisory Board Chair seeking clinical practice and gut health outcomes for the CRE
The Centre of Research Excellence in Digestive Health is delighted to announce that Emeritus Professor Fred D’Agostino has graciously accepted an invitation to the role of Chair of the CRE Advisory Board. Fred D’Agostino is the Emeritus Professor of Humanities at The University of Queensland, where he was previously President…
CRE Introduction
In this video, Chief Investigator Professor Nicholas Talley explains how more than 100 researchers from the CRE Digestive Health are collaborating in a bold attempt to unravel the mysteries around unexplained gut disorders.
Our Advisory Board Meeting
On August 19th, our inaugural NHRMC CRE Digestive Health Advisory Board meeting was held virtually. The group of International and Australian Board Members contributed to discussions about the digestive health research concepts and ideas tabled by the Chief Investigators. Updates and presentations about CRE progress in the first year were…
AGITG 2021: Save the date!
Australasian Gastro-Intestinal Trials Group 23rd Annual Scientific Meeting 12-15 October 2021 Sofitel Melbourne on Collins Convenor: Professor Stephen Ackland asm.gicancer.org.au The AGITG Annual Scientific Meeting serves not only as a forum for the presentation of state-of-the art overviews on the pathobiological and clinical aspects of GI cancer, but also affords the…
HMRI 2020 Research Excellence Award goes to Distinguished Laureate Professor Nick Talley AC.
Nov 12 2020 The Hunter’s researchers and their community supporters gathered with representatives from Hunter Medical Research Institute (HMRI), the University of Newcastle, and HNE Local Health District to virtually celebrate and honour medical research excellence at the annual HMRI Awards Night – HMRI 2020 – on Thursday (November 12)…
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